New Cytotoxic Cembranes from the Sea Pen <i>Gyrophyllum </i><i>s</i><i>ibogae</i>
2004-07-23T00:00:00Z (GMT) by
Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen <i>Gyrophyllum sibogae </i>collected in South Africa: 7,8-dihydroflabellatene A (<b>1</b>) and 7,8-dihydroflabellatene B (<b>2</b>). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite <b>1</b>, which showed strong in vitro cytotoxicity against a panel of 13 tumor cell lines.
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