gnpl_a_1419238_sm6740.pdf (1.1 MB)
New 2-arylbenzofurans from the root bark of Artocarpus gomezianus and their α-glucosidase inhibitory activity
journal contribution
posted on 2017-12-28, 05:23 authored by Poomraphie Nuntawong, Virunh Kongkatitham, Kittisak Likhitwitayawuid, Wanwimon Mekboonsonglarp, Suchada Sukrong, Somboon Tanasupawat, Boonchoo SritularakTwo new 2-arylbenzofurans, namely 13-O-methyllakoochin B (1) and artogomezianin (2), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3–8). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2) and lakoochin A (3) exhibited strong α-glucosidase inhibitory activity with IC50 values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose.