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Near-Infrared-Triggered Dynamic Surface Topography for Sequential Modulation of Macrophage Phenotypes
journal contribution
posted on 2019-11-08, 22:30 authored by Xiaowen Zheng, Liaobing Xin, Yilun Luo, Huang Yang, Xingyao Ye, Zhengwei Mao, Songying Zhang, Lie Ma, Changyou GaoImmune
response is critical to tissue repair. Designing biomaterials
with immunomodulatory functions has become a promising strategy to
facilitate tissue repair. Considering the key roles of macrophages
in tissue repair and the significance of the balance of M1 and M2,
smart biomaterials, which can harness macrophage phenotypes dynamically
to match the tissue healing process on demand, have attracted a lot
of attention to be set apart from the traditional anti-inflammatory
biomaterials. Here, we prepare a gold nanorod-contained shape memory
polycaprolactone film with dynamic surface topography, which has the
ability to be transformed from flat to microgrooved under near-infrared
(NIR) irradiation. Based on the close relationships between the morphologies
and the phenotypes of macrophages, the NIR-triggered surface transformation
induces the elongation of macrophages, and consequently the upregulated
expressions of arginase-1 and IL-10 in vitro, indicating the change
of macrophage phenotypes. The sequential modulation of macrophage
phenotypes by dynamic surface topography is further confirmed in an
in vivo implantation test. The healing-matched modulation of macrophage
phenotypes by dynamic surface topography without the stimuli of cytokines
offers an effective and noninvasive strategy to manipulate tissue
regenerative immune reactions to achieve optimized healing outcomes.
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Keywords
tissue healing processNear-Infrared-Triggered Dynamic Surface Topographygold nanorod-contained shape memory polycaprolactone filmoptimized healing outcomesvivo implantation testbiomaterialmacrophage phenotypestissue repairMacrophage Phenotypes Immune responseNIR-triggered surface transformationsurface topographyIL
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