np6b01157_si_002.pdf (3.03 MB)
Natural Products of Picea Endophytes from the Acadian Forest
journal contribution
posted on 2017-04-11, 16:21 authored by David
R. McMullin, Blake D. Green, Natasha C. Prince, Joey B. Tanney, J. David MillerEndophytes of healthy needles were
collected from Picea
rubens (red spruce) and P. mariana (black
spruce) in a survey of southeastern New Brunswick, Canada. Four endophyte
strains were selected for further investigation based on the production
of biologically active extracts from culture filtrates during screening
as well as phylogenetic relationship to species known to produce natural
products or taxonomic novelty. A novel endophyte within the family
Rhytismataceae produced two new dihydropyrones (1 and 2) as major metabolites together with phthalides (3 and 4), isocoumarins (5 and 6), and tyrosol (7). Lachnum cf. pygmaeum synthesized a new chlorinated para-quinone, chloromycorrhizinone A (8), and the nematicidal
compounds (1′Z)-dechloromycorrhizin A (9), mycorrhizin A (10), and chloromycorrhizin
A (11). A new isocoumarin (12) and four
related structures (13–16) were isolated
from an undescribed taxon in the Mycosphaerellaceae. The known antifungal
metabolites cryptosporiopsin (17), 5-hydroxycryptosporiopsin
(18), (+)-cryptosporiopsinol (19), and mellein
(20) were produced by Pezicula sporulosa. Phylogenetically diverse conifer endophytes from the Acadian forest
continue to be a productive source of new biologically active natural
products.
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Lachnum cfP . marianaAcadian forestculture filtratesantifungal metabolites cryptosporiopsinfamily Rhytismataceaephylogenetic relationshipNatural Productsconifer endophytesisocoumarinchlorinated paraPezicula sporulosaAcadian Forest Endophytesendophyte strainsPicea EndophytesPicea rubensNew Brunswicktaxonomic novelty. marianaundescribed taxonnovel endophyte
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