Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biological effects

Crisalli, Meredith A.; Franco, Lilian P.; Silva, Bruno R.; Holanda, Alda K. M.; Bendhack, Lusiane M.; Da Silva, Roberto S.; Ford, Peter C.

doi:10.6084/m9.figshare.6189044.v2

gcoo_a_1469129_sm3251.docx (83.27 kB)

Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biological effects

Version 2 2018-05-16, 04:17

Version 1 2018-04-26, 13:18

journal contribution

posted on 2018-05-16, 04:17 authored by Meredith A. Crisalli, Lilian P. Franco, Bruno R. Silva, Alda K. M. Holanda, Lusiane M. Bendhack, Roberto S. Da Silva, Peter C. Ford

This research presents the synthesis and characterization of the photochemical nitric oxide (NO) precursor Ru(salenCO₂H)(NO)Cl (1, salenCO₂H = N,N’-ethylenebis(3,3’-bis-carboxylsalicylideneiminato). This water-soluble ruthenium nitrosyl releases NO upon photolysis with a quantum yield that is pH dependent owing to the nitrosyl to nitrite conversion of that axial ligand at higher pH. Also described are the water, oxygen, and thermal stability of 1 and the cytotoxicity and the vascular relaxivity properties of 1 in the dark and under photolysis.