np300792t_si_001.pdf (1.18 MB)
Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus Mycoleptodiscus sp. F0194
journal contribution
posted on 2013-04-26, 00:00 authored by Humberto
E. Ortega, Paul R. Graupner, Yumi Asai, Karen TenDyke, Dayong Qiu, Young Yongchun Shen, Nivia Rios, A. Elizabeth Arnold, Phyllis D. Coley, Thomas
A. Kursar, William H. Gerwick, Luis Cubilla-RiosTwo novel reddish-orange alkaloids,
mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid
cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using
1D and 2D NMR spectroscopy in combination with IR spectroscopic and
MS data. These compounds are indole-terpenes with a new skeleton uncommon
in nature. Mycoleptodiscin B (2) was active in inhibiting
the growth of cancer cell lines with IC50 values in the
range 0.60–0.78 μM.