Multivalent Ligands as Chemical Probes for the Investigation of Dopamine D2 Receptor Pharmacology

2017-09-10T23:44:40Z (GMT) by ANITHA KOPINATHAN
The dopamine D<sub>2</sub> receptor is a well-established therapeutic target for the treatment of central nervous system disorders such as schizophrenia and Parkinson’s disease. Although a number of treatments have been developed to target this receptor, our understanding of the structural and pharmacological aspects of the dopamine D<sub>2</sub> receptor are still in its infancy. This thesis describes the design, synthesis and biological evaluation of chemical probes to investigate the structure and pharmacology of the dopamine D<sub>2</sub> receptor. Through this work, it is envisaged that these probes will aid the development of novel treatments for central nervous system disorders with reduced side-effects.