Multiple cleavage sites in a poly(A) site

<p><b>Copyright information:</b></p><p>Taken from "A large-scale analysis of mRNA polyadenylation of human and mouse genes"</p><p>Nucleic Acids Research 2005;33(1):201-212.</p><p>Published online 12 Jan 2005</p><p>PMCID:PMC546146.</p><p>© 2005, the authors © </p> () Histogram of the genomic distance between adjacent cleavage sites in genes. () Histogram of the distance between the 5′-most cleavage site and other downstream cleavage sites when multiple cleavage sites are present in a poly(A) site (mean = 7.9 nt, median = 5 nt). () The relationship between the number of PAS hexamers (AAUAAA and other 11 variants) associated with a poly(A) site and the number of cleavage sites in the poly(A) site. Error bars are standard error of the mean (SEM). () Correlation between the number of cleavage sites and the number of supporting cDNA/EST sequences for poly(A) sites (Pearson correlation coefficient = 0.83). () Histogram of the distance between a poly(A) site and the associated PAS when only one PAS is present. Only human poly(A) sites are used in (A–E).

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