Multicomponent synthesis and anticancer activity studies of novel 6-(Trifluoromethyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives

<p>A series of novel 6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were obtained in good yields from ethyl 4,4,4-trifluoro-3-oxobutanoate, urea, and aryl aldehyde via Biginelli multicomponent reaction. All the corresponding products <b>4a–4p</b> were examined against four human cancer cell lines (A549, HepG2, COLO205 and DU145) and compounds <b>4e</b>, <b>4i</b>, and <b>4 m</b> which showed promising anticancer activity have been identified.</p>