Multicomponent Approach in the Synthesis of 2,2,6-Trisubstituted Morpholine Derivatives

2016-02-20T08:33:42Z (GMT) by Jing Zhou Ling Zhou Ying-Yeung Yeung
An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, <i>N</i>-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification.