Multi-viral dosing scheme under scenario 1.

Plots of the susceptible normal and tumor cell populations when a virus is administered at three successive times, with a viral dose of V = 10⁹ pfu when . Fig 4(a) shows how the oncolytic virus reduces the susceptible normal cell population during multiple-viral dose scheme. Fig 4(b) shows how successive viral doses can lead to tumor eradication or at least keep the tumor in transient dormancy, which is followed by tumor relapse.