ol5b00376_si_001.pdf (4 MB)
Monocarboxylation and Intramolecular Coupling of Butenylated Arenes via Palladium-Catalyzed C–H Activation Process
journal contribution
posted on 2015-03-20, 00:00 authored by Rui Liu, Ze-Hai Lu, Xiao-Hui Hu, Jun-Li Li, Xian-Jin YangA novel
and practical reaction for the direct intramolecular oxidative coupling
of butenylated arenes is reported. With the catalysis of Pd(OAc)2, reactions of various butenylated arenes and carboxylic acids
with Selectfluor reagent in CH3CN solution afforded the
corresponding monocarboxylation/cyclization products in good yields
under mild conditions. This research demonstrated an economic method
with the synthesis of 2-tetralyl carboxylic esters, a valuable class
of bioactive compounds.