Molecular markers for colon cancer – from bench to bedside: Molecular subclassification

Overview
- Limitations of adenoma-carcinoma sequence as genetic model for colorectal tumorigenesis
- Genetic instability and DNA methylation as main features for molecular classification
- Colo-rectal carcinoma molecular classification
* Clinical features
* Pathological-molecular correlation
Molecular classification of colo-rectal carcinomas is mainly based on:
- Main pathways: Adenomatous (APC ± KRAS, hypo-CH3) and serrated (BRAF, CIMP-high)
- Microsatellite profiles further subclassify each group.
- CIMP-low represents a new epigenomic subtype (KRAS)