Molecular Recognition of Carbohydrates with Acyclic Pyridine-Based Receptors
2004-10-29T00:00:00Z (GMT) by
The recognition capabilities of acyclic pyridine-based receptors toward monosaccharides were evaluated. Aminopyridine receptors based on the 2,4,6-trimethyl- or 2,4,6-triethylbenzene frame show high β vs α binding selectivity in the recognition of glucopyranosides. Amidopyridine receptors, which are sterically less hindered at nitrogen, display high efficiency and an inverse selectivity. The 2-aminopyridine group has been established as a highly effective recognition group in the binding of monosaccharides. The factors influencing the binding properties of receptors 1−15, which differ in the nature and number of binding and spacer subunits used as the buildings blocks, are discussed.