Modelling and design of inhibitors targeting the interaction between HIV integrase and lens epithelium-derived growth factor

2014-03-17T23:25:04Z (GMT) by Sandra Giuliani
<p>Dissertation submitted and defended in March 2012 by Sandra Giuliani as a requirement of the MSc in Chemistry and Pharmaceutical Technologies (Corso di Laurea in Chimica e Tecnologia Farmaceutiche), University of Bologna, Italy.</p> <p> </p> <p><strong>Aim of the work</strong>: design of novel inhibitors of the HIV integrase/LEDGF protein-protein interaction</p> <p><strong>Techniques/approaches</strong>: molecular docking (for screening of small-molecule/fragment inhibitors); conformational searching/docking/de novo design of cyclic peptides; molecular dynamics simulations</p> <p><strong>Research work carried out at</strong>: Monash Institute of Pharmaceutical Sciences, Monash University, Australia.</p> <p><strong>Supervisor:</strong> Dr David Chalmers (Monash University)</p> <p><strong>Thesis Advisor:</strong> Prof. Andrea Cavalli (University of Bologna)</p> <p> </p>