Model of gene expression within a cell

2011-12-30T14:12:16Z (GMT) by Su-In Lee Serafim Batzoglou

Copyright information:

Taken from "Application of independent component analysis to microarrays"

Genome Biology 2003;4(11):R76-R76.

Published online 24 Oct 2003


Copyright © 2003 Lee and Batzoglou; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Each genomic expression pattern at a given condition, denoted by , is modeled as linear combination of genomic expression programs of independent biological processes. The level of activity of each biological process is different in each environmental condition. The mixing matrix contains the linear coefficients , where = activity level of process in condition . The example shown uses data generated by Gasch . [].




CC BY 4.0