Model assumptions and FE mesh generation from EM image cross-sections.

(A): We assumed that individual mitochondria that cluster together will share a common inner membrane space. (B): Based on this assumption, each mitochondrial cluster was divided into two regions: an IMS region, depicted in green and a matrix region, depicted in blue. A third region depicted in red covers the myofibrils present in the cell. (C): Image of a FE mesh developed from the EM image of cross-section 1 with the three different regions.