pcbi.1006640.g003.tif (2.47 MB)
Model assumptions and FE mesh generation from EM image cross-sections.
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posted on 2018-12-05, 19:09 authored by Shouryadipta Ghosh, Kenneth Tran, Lea M. D. Delbridge, Anthony J. R. Hickey, Eric Hanssen, Edmund J. Crampin, Vijay Rajagopal(A): We assumed that individual mitochondria that cluster together will share a common inner membrane space. (B): Based on this assumption, each mitochondrial cluster was divided into two regions: an IMS region, depicted in green and a matrix region, depicted in blue. A third region depicted in red covers the myofibrils present in the cell. (C): Image of a FE mesh developed from the EM image of cross-section 1 with the three different regions.
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mitochondrial CK enzymesimpactelectron microscope imagesmetabolite distributionscreatine phosphatebioenergeticmitochondria aggregatedmitochondrial distributionsforce productionmitochondrial arrangementtwitch durationreactions actcell cross-sectioncell architectureforce dynamicsmitochondrial organizationuniform force dynamicsdiffusionhypoxia activityuniform ATPcreatine kinaseelement modelingelectron microscopy dataPCr shuttlemitochondrial organisationforce generationADP ratiosphosphate compounds
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