Missense Mutation of POU Domain Class 3 Transcription Factor 3 in <i>Pou3f3<sup>L423P</sup></i> Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle - Fig 8

<p><b>Number of glomeruli per kidney and mean glomerular volumes in 12-day-old (A, C) and 60-week-old (B, D) <i>Pou3f3</i></b><sup><b><i>L423P</i></b></sup><b>mutant mice and non-mutant control mice.</b> The numbers of examined animals are given in parentheses. Data are means ± SD. Significant differences between homozygous and heterozygous mutants and non-mutant control mice are indicated by asterisks. *: p < 0.05, **: p < 0.01, ***: p < 0.001. Significant differences between male and female mice of identical genotypes are indicated by crosses. +: p < 0.05, ++: p < 0.01, +++: p < 0.001.</p>