U190849.pdf (5.53 MB)
Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles
thesis
posted on 2014-12-15, 10:36 authored by Laurence OleksikInitially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported. The selective synthesis of a range of alpha-aryl vinyl ethers using Heck chemistry is then reported. Subsequent perfluoroacylations of the vinyl ethers followed by reaction of the resulting perfluoroacyl enol ethers with hydrazine affords a range of 5-aryl-3-perfluoroalkyl pyrazoles in good yields.;Alternative methodology for the synthesis of 5-aryl-3-perfluoroalkyl pyrazoles is then described in which resin bound esters are converted to vinyl ethers
History
Date of award
2004-01-01Author affiliation
ChemistryAwarding institution
University of LeicesterQualification level
- Doctoral
Qualification name
- PhD