Meta-Analysis of Associations Between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis

<div><p><i>Objective</i>: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis.</p><p><i>Methods</i>: A meta-analysis was conducted of the associations between the IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and vasculitis.</p><p><i>Results</i>: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780–1.102, <i>p</i> = 0.389). However, disease-specific meta-analysis showed an association between Wegener’s granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547–0.971, <i>p</i> = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706–0.916, <i>p</i> = 0.001) in all study subjects and Behcet’s disease (BD) (OR = 0.724, 95% CI = 0.679–0.781, <i>p</i> < 1.0 × 10<sup>−9</sup>). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619–0.938, <i>p</i> = 0.005) and BD (OR = 0.718, 95% CI = 0.661–0.781, <i>p</i> < 1.0 × 10<sup>−9</sup>). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105–1.513, <i>p</i> = 0.035).</p><p><i>Conclusions</i>: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.</p></div>