ol6b02154_si_001.pdf (3.39 MB)
Manganese-Catalyzed Carboacylations of Alkenes with Alkyl Iodides
journal contribution
posted on 2016-08-09, 15:53 authored by Caitlin
M. McMahon, Matthew S. Renn, Erik J. AlexanianA manganese-catalyzed
carboacylation of alkenes with alkyl iodides
and carbon monoxide is described. This carbonylative difunctionalization
uses both primary and secondary alkyl iodides in reactions with a
diverse array of cyclic and acyclic substrates. Examples of successful
applications to the synthesis of five-, six-, and seven-membered rings
are provided. The inexpensive, first-row catalytic system and mild
reaction conditions are expected to facilitate applications in complex
synthesis.