MOESM3 of SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation

Additional file 3: Figure S3. SMYD5 and H4K20me3 are enriched at LINE and LTR repeats in ES cells. (A) Repetitive DNA sequences (LINE and LTR) are enriched in H4K20me3, H3K9me3 and SMYD5 genomic sites. Comparison of H4K20me3, H3K9me3, and SMYD5 enriched sequences and annotated repetitive sequences ( http://www.repeatmasker.org ). The percentage of ChIP-enriched regions with at least 60% repeat length is shown. Note the predominance of LTR and LINE repetitive DNA sequences in ChIP-enriched islands. (B) Repeat subfamilies belonging to the LINE and LTR repetitive DNA sequence classes are enriched in H4K20me3, H3K9me3 and SMYD5 genomic sites. The percentage of ChIP-enriched regions with at least 60% repeat length is shown. (C) Repetitive DNA sequence family members L1 and ERVK are enriched in H4K20me3, H3K9me3 and SMYD5 genomic regions.