MOESM1 of Arbutin encapsulated micelles improved transdermal delivery and suppression of cellular melanin production

Additional file 1. Figure S1. Concentration-UV absorption relationship of melanin. Figure S2. Daily imaging of B16-F10 mouse melanoma cells during a 5-day culturing with allantoin, arbutin, glycolic acid, or hyaluronic acid at various concentrations. Figure S3. Photos of diluted PBS solution of micellar arbutin cream (MA), blank cream (BM), and non-micellar arbutin cream (NMA) and their Hydrodynamic diameters. Figure S4. Daily imaging of B16-F10 mouse melanoma cells during a 5-day culturing with blank cream, free arbutin, micellar arbutin cream, and non-micellar arbutin cream. Figure S5. HPLC analysis of arbutin in the receiving well during the skin penetration experiment at different hours. Figure S6. Relationship between the arbubin concentrations and peak area in the HPLC measurement. Figure S7. Concentration of glucosamine in blood plasma upon oral administration of glucosamine solution and topical application of URAH micellar glucosamine cream.