MOESM18 of Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

Additional file 18. The functionally grouped networks of GO terms and pathways with associated genes for artemisinin resistance background genes set (57 genes), obtained by overlapping KHA specific genes (467 genes) and ART-R subpopulations specific genes (97 genes). This network represents the associations between the GO terms based on the similarity of the genes. The nodes represent the GO terms and the edges are the associations based on kappa score, which is also used for defining functional groups. Each functional group is represented with the most significant GO term in the functional group. The “Triangles” represent the metabolic pathways, “Ellipse” represents the GO terms associated to biological processes, “Hexagon” represents the GO terms associated to cellular component and the “Rectangles” represent the GO terms associated to Molecular functions. Different colors signify different GO terms functional groups. Nodes with more than one color represents the GO terms included in more than one functional group. The network of GO terms functional group is built in Cytoscape v3.2.1 using the plugin ClueGO v2.2.4.