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Lorneic Acid Analogues from an Endophytic Actinomycete
journal contribution
posted on 2017-10-09, 14:11 authored by Ruimin Yang, Jing Yang, Li Wang, Jian-Ping Huang, Zijun Xiong, Jianying Luo, Mingming Yu, Yijun Yan, Sheng-Xiong HuangOur
natural products discovery program utilizes endophytic actinomycetes
associated with plants and employs biological assays and HPLC-based
metabolite profiles as the preliminary screen to identify strains
of interest, followed by large-scale fermentation and isolation, leading
to new and/or bioactive natural products. Six new trialkyl-substituted
aromatic acids, namely, lorneic acids E–J (1–6), together with two known analogues (7 and 8), were isolated and identified from the culture extract
of Streptomyces sp. KIB-H1289, an endophytic
actinomycete obtained from the inner tissue of the bark of Betula mandshurica Nakai. The structures were characterized
by interpretation of their spectroscopic data, mainly 1D and 2D NMR.
Among them, compound 5 contains a unique disulfide bond
that is presumably derived from N-acetylcysteine.
All isolated metabolites were evaluated for their inhibitory activity
on tyrosinase.
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interpretationspectroscopic datacompound 5products discovery programstraintissueStreptomyces spanalogueacidbarkendophytic actinomycetes1 DHPLC-based metabolite profileslorneicendophytic actinomyceteassaytrialkyl-substitutedacetylcysteineBetula mandshurica Nakai2 D NMRcultureisolationEndophytic ActinomyceteKIB-Hdisulfide bondbioactivetyrosinaseAnalogueLorneic
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