ab8b01138_si_001.pdf (1.1 MB)
Loquat-Inspired Janus Drug Delivery System for Flexible and Robust Tumor Targeting Therapy
journal contribution
posted on 2019-01-02, 00:00 authored by Yu Liu, Chaochao Wei, Long Huang, Weizhu Liu, Jiaqi Lin, Leifeng Chen, Yalan Yang, Ping Hu, Anwen Liu, Xiaolei WangWith
the inspiration of the shape of the loquat fruit, here, we
developed a similarly shaped Janus carrier. This peculiar gold rod-partially
exposed structure not only significantly increased the drug loading
capability but also improved its infrared response efficiency. A better
effect of drug-photothermal treatment thus could be realized. With
the aid of an external 3D printed drug guiding device, this carrier
could accurately reach different affected areas. The subsequent infrared
triggered multiple tumor therapy, thus, could be conducted in the
designated location. The corresponding experimental results demonstrated
the reliability, flexibility, and biocompatibility of the proposed
drug delivery system for two different tumor targeting treatments.