Loading of Hydrophobic Materials into Polymer Particles:  Implications for Fluorescent Nanosensors and Drug Delivery

2005-10-05T00:00:00Z (GMT) by Huiguang Zhu Michael J. McShane
A straightforward method for loading hydrophobic materials into commercially available polymer nano- or microparticles is described. PMMA and PS nano/microparticles were swelled by an organic solvent with an ionic surfactant (SDS) to stabilize the particles in aqueous solution. FITC and Ru(dpp)<sub>3</sub>Cl<sub>2</sub> were loaded into those particles based on the principle of “like dissolves like”. Further surface modification of the loaded particles was achieved via layer-by-layer (LbL) self-assembly. Culture of fibroblasts with the dye-doped, coated particles showed that the cells internalized the fluorescent particles with no apparent toxic effects. The findings suggest the facile process could be useful in a wide range of applications for fluorescent micro/nanosensors and drug delivery.