Lithium Database of Human Studies (version 1.0) --PubMed & ClinicalTrials.gov
Google SpreadSheet Open (URL below)
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Evidence has been cherry-picked,(1) a logical fallacy not exclusive to lithium.(2,3) This phenomenon is also frequently seen when the published evidence of many drugs (psychiatric and non-psychiatric active pharmacological principles) is weighted up against the hidden data of unpublished studies:
– Animal models and in vitro studies on isolated tissues, and cell cultures
– Pharmacokinetic and pharmacodynamic information
– Interventional human studies: clinical trials — e.g., controlled (randomized or non-randomized), single-arm (i.e., uncontrolled trials), cross-over, among other study designs. (read more: Circulation.2007; 115: 1164-1169).
– Observational epidemiological studies (e.g., case-control, cohort, cross-sectional).
– Other types of pharmacological evidence.(3)
2. Lithium have one of the narrowest therapeutic index among drugs approved into the market by regulatory agencies (e.g., FDA, EMA, INVIMA, among others).(1, 4-6)
References
Ramirez, Jorge H (2014): Lithium Database of Human Studies (version 1.0) –PubMed & ClinicalTrials.gov. figshare.
http://dx.doi.org/10.6084/m9.figshare.1281222
— Google SpreadSheet Database: https://docs.google.com/spreadsheets/d/1XMKsggpf1ViFzfVo8qY47kJYT5H4zzDP-LUIilFjkrc/edit#gid=1390342057
Ramirez, Jorge H (2015): Evidence Live 2015: Analysis of US phase 3 ClinicalTrials.gov records completed before January 1st, 2011 (n=5051; time frame: 2002 to 2014). figshare. http://dx.doi.org/10.6084/m9.figshare.1286769
Re: Are clinical trial data shared sufficiently today? No BMJ 2013; 347
http://www.bmj.com/content/347/bmj.f1880/rr/763200
Lithium Toxicity: http://emedicine.medscape.com/article/815523-overview#showall
PubChem – Lithium: http://pubchem.ncbi.nlm.nih.gov/compound/3028194
IUPHAR/BPS – Guide to Pharmacology: Li+
http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=summary&ligandId=5212
