mp049936v_si_001.pdf (195.73 kB)
Liposomal Surface-Loading of Water-Soluble Cationic Iron(III) Porphyrins as Anticancer Drugs
journal contribution
posted on 2004-09-13, 00:00 authored by Makoto Yuasa, Kenichi Oyaizu, Aiko Horiuchi, Akihiko Ogata, Tomomi Hatsugai, Aritomo Yamaguchi, Hiroyoshi KawakamiA novel design of anticancer drug delivery
system, based on an electrostatic binding of negatively
charged liposomes and cationic metalloporphyrins under
physiological conditions, is reported. A lack of cytotoxicity
of the iron(III) porphyrin-loaded liposomes and an efficient
generation of a toxic hydroxyl radical (OH•) from a superoxide anion radical (O2-•) through the iron(III)-catalyzed
dismutation and the Fenton-like reaction allow for a
targeted necrosis of tumor cells where the concentration
of O2-• is locally increased as a result of the reduced
activity of superoxide dismutase and catalase in these
cells.Keywords: Anticancer drug delivery system; liposome; cationic metalloporphyrins; superoxide anion radical; hydroxyl
radical