Lignans from the shed trunk barks of the critically endangered plant <i>Abies beshanzuensis</i> and their anti-neuroinflammatory activities

<p>During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant <i>Abies beshanzuensis</i>, one new (<b>1</b>) and ten known (<b>2</b>–<b>11</b>) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7<i>S</i>,8<i>R</i>,8′<i>R</i>)-4′-methoxyl-<i>α</i>-conidendrin (<b>1</b>). Among the isolated lignans, (−)-matairesinol (<b>5</b>) and (−)-arctigenin (<b>6</b>) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide in lipopolysaccharide-stimulated murine BV-2 microglial cells, with IC<sub>50</sub> values of 11.5 and 19.0 μM, respectively.</p>