Lignans from the seeds of Chinese hawthorn (<i>Crataegus pinnatifida</i> var<i>. major</i> N.E.Br.) against β-amyloid aggregation

<p>Phytochemical investigation on the seeds of hawthorn (<i>Crataegus</i> spp.) led to the isolation of a new compound, (7′<i>R</i>, 8′<i>R</i>, 8<i>S</i>)-isolariciresinol (<b>1</b>), along with six known compounds (<b>2–7</b>). The structures of all compounds were determined based on spectroscopic data interpretation. The Aβ<sub>1–42</sub> inhibition activity of all isolated compounds was evaluated <i>in vitro</i>. As a result, compounds <b>5</b> and <b>6</b> showed stronger inhibition of Aβ<sub>1–42</sub> aggregation than curcumin, with inhibition rates of 70.59 and 68.14% at 20 μM. The possible mechanism of interaction between Aβ<sub>1–42</sub> and the active compounds <b>5</b> and <b>6</b> was also investigated by molecular docking.</p>