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Lewis acid catalyzed Povarov reaction of pentafulvenes and spiro[2,4]-hepta-[4,6]-diene: An efficient access to cyclopentene fused quinolines
Version 2 2018-03-19, 18:11
Version 1 2018-03-06, 15:25
journal contribution
posted on 2018-03-19, 18:11 authored by Shreyass Saranya, Thekke Veettil Baiju, Greeshma Gopalan, Kokkuvayil Vasu RadhakrishnanAn efficient protocol for the Lewis acid catalyzed three-component aza-Diels-Alder reaction of pentafulvenes as dienophile has been developed. Cyclopentene fused tetrahydroquinolines were formed in good yields with excellent diastereoselectivities. The method was extended to spiro[2,4]hepta-4,6-diene, by which 3,4-dihydroquinoline derivatives were obtained. The aromatization of cycloadducts furnished corresponding quinoline derivatives.