ol5b02556_si_002.cif (407.88 kB)
Lewis Acid Catalyzed Tandem Polycyclization of Internal Alkynols and Vinyl Azides
dataset
posted on 2015-11-06, 00:00 authored by Hai Xiao Siyang, Xiao Yue Ji, Xu Rui Wu, Xin Yan Wu, Pei Nian LiuA novel Lewis acid
catalyzed tandem cyclization reaction of internal
alkynols and vinyl azides has been achieved to afford a series of
products containing a pyran-based indeno[1,2-c]isochromene
scaffold in moderate to high yields. This tandem polycyclization protocol
provides a straightforward entry to construct the complex polycyclic
skeleton through cycloisomerization, formal [4 + 2] cycloaddition,
and an elimination process.