Lewis Acid Catalyzed Tandem Polycyclization of Internal Alkynols and Vinyl Azides
2015-11-06T00:00:00Z (GMT) by
A novel Lewis acid catalyzed tandem cyclization reaction of internal alkynols and vinyl azides has been achieved to afford a series of products containing a pyran-based indeno[1,2-c]isochromene scaffold in moderate to high yields. This tandem polycyclization protocol provides a straightforward entry to construct the complex polycyclic skeleton through cycloisomerization, formal [4 + 2] cycloaddition, and an elimination process.
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