Lewis Acid Catalyzed Regioselective Hydroheteroarylation
of Pentafulvenes

Chand, S. Sarath; Gopalan, Greeshma; Santhini, P. V.; Preethanuj, P.; John, Jubi; Harakat, Dominique; Jaroschik, Florian; Radhakrishnan, K. V.

doi:10.1021/acs.orglett.6b00047.s001

ol6b00047_si_001.pdf (12.95 MB)

Lewis Acid Catalyzed Regioselective Hydroheteroarylation of Pentafulvenes

journal contribution

posted on 2016-02-10, 00:00 authored by S. Sarath Chand, Greeshma Gopalan, P. V. Santhini, P. Preethanuj, Jubi John, Dominique Harakat, Florian Jaroschik, K. V. Radhakrishnan

A diverse approach toward the catalytic regioselective nucleophilic addition of nitrogen heterocycles to Lewis acid activated pentafulvenes has been established. The developed protocol introduces pentafulvenes as nonsymmetrical alkenes for the hydroheteroarylation reaction, providing alkylidenecyclopentenylation at the C-3 position of indoles and the C-2 position of pyrrole.