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Levan and levansucrases: Polymer, enzyme, micro-organisms and biomedical applications

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posted on 2017-04-25, 14:29 authored by Álvaro González-Garcinuño, Antonio Tabernero, Ángel Domínguez, Miguel A. Galán, Eva M. Martin del Valle

Nowadays, levan synthesis and its biocatalysis is a step claiming attention due to its promising uses in biomedical field. Levansucrase, as the enzyme responsible of levan biocatalysis is studied in this work concerning sequence homology, signal peptide, metal binding, etc. More than 650 different levansucrase sequences were studied and many interesting results were obtained such as phylogenetic trees and conserved residues that could be essential for biocatalysis machinery. Moreover, a review of levan applications in biomedicine and health field was made. It is showed the advances in applications such as a film agent, a carrier for drug delivery systems, an anti-inflammatory compound or its potential use for functional food as prebiotic.

Funding

Authors want to acknowledge Spanish Ministry of Economy and Competitiveness for funding support (Project code: CTQ2016-78988-R). Álvaro González-Garcinuño also acknowledges his PhD grant (F. P. U.) from the Ministry of Education, Culture and Sports, Spain (Ref. FPU14/04914).

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