la5b04762_si_002.avi (331.59 kB)
Leucocyte Membrane-Coated Janus Microcapsules for Enhanced Photothermal Cancer Treatment
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posted on 2016-03-29, 00:00 authored by Wenping He, Johannes Frueh, Zhenwei Wu, Qiang HePolyelectrolyte
multilayer (PEM) capsules are promising candidates
for many kinds of cancer detection and treatment but are usually intended
to deliver cargo to specific sites or to destroy cancer cells based
on photothermal effects from the outside. In this publication we prove
that it is possible to kill cancer cells from the inside based on
phagocytosed PEM capsules. In addition we show how to open the cells
and bring the PEM capsules to the surface of cancer cells based on
photothermal effects and rapid evaporation of water. Diffusion-based
temperature determinations of the photothermal effect up to the evaporation
temperature of water are presented.