Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

2009-05-21T00:00:00Z (GMT) by Ho Yong Lee Xuan Jiang Dongwhan Lee
A counterintuitive observation of <i>a faster signal relay over a longer linear distance</i> prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient “shortcut” that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.