Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?
2009-05-21T00:00:00Z (GMT) by
A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient “shortcut” that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.
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