figshare
Browse
lsta_a_1395045_sm2948.docx (209.41 kB)

Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies

Download (209.41 kB)
journal contribution
posted on 2017-10-23, 15:03 authored by Mulugeta Gebregziabher, Mark A. Eckert, Lois J. Matthews, Abeba A. Teklehaimanot, Judy R. Dubno

Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model (mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.

Funding

National Institute on Deafness and Other Communication Disorders(10.13039/100000055, P50 DC000422), National Institutes of Health(10.13039/100000002, UL1 RR029882)

History

Usage metrics

    Communications in Statistics - Theory and Methods

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC