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Isopalhinine A, a Unique Pentacyclic Lycopodium Alkaloid from Palhinhaea cernua

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posted on 2013-07-19, 00:00 authored by Liao-Bin Dong, Xiu Gao, Fei Liu, Juan He, Xing-De Wu, Yan Li, Qin-Shi Zhao
A new pentacyclic (5/6/6/6/7) Lycopodium alkaloid named isopalhinine A (1), which possesses a sterically congested architecture built with a tricyclo[4.3.1.03,7]decane (isotwistane) moiety and a 1-azabicyclo[4.3.1]decane moiety, and palhinines B (2) and C (3) were isolated from Palhinhaea cernua. The structure and absolute configuration of 1 were elucidated by a combination of NMR spectra, optical rotation calculation, and X-ray diffraction experiment. A possible biogenetic pathway was also proposed.

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