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Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants
journal contribution
posted on 2008-01-25, 00:00 authored by José C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz Caviedes, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. HammondThe antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′-dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.
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PlantsTheMycobacterium tuberculosisantiproliferativefractionationacidAmazonianTargetednontumorigenic cell linesinvestigationidentificationdihydroxyDoliocarpus dentatusIryanthera juruensistumor cell linesIsolationcytotoxic constituentsbetulinicCytotoxic MetabolitesMedicinalPicramnia sellowiiPeruvian plantsbisnordihydrotoxyferineStrychnos mitscherlichiiisolationCroton alnifolius
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