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Isolation and synthesis of a new benzylated alkamide from the roots of Lepidium meyenii

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posted on 2018-08-20, 12:48 authored by Yan-Qing Ye, Zu-Hong Ma, Qiao-Fen Yang, Yan-Qi Sun, Rui-Qi Zhang, Run-Fang Wu, Xin Ren, Li-Juan Mu, Zhi-Yong Jiang, Min Zhou

A new benzylated alkamide, N-(3,4-dimethoxybenzyl)-9Z-oleamide (1), along with two known ones (2 and 3) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan Province of China. Their structures were elucidated by extensive spectroscopic analyses and the new compound further confirmed by a one-step synthesis. All the isolated alkamides were evaluated for their cytotoxicity against five human cancer cell lines. However, no significant activities were detected at concentrations up to 40 μM.

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