np400388x_si_003.pdf (13.59 MB)
Isolation, Structures, and Biological Activities of Triterpenoids from a Penares sp. Marine Sponge
journal contribution
posted on 2013-09-27, 00:00 authored by Sophia
A. Kolesnikova, Ekaterina G. Lyakhova, Anatoly I. Kalinovsky, Michail A. Pushilin, Shamil Sh. Afiyatullov, Ekaterina A. Yurchenko, Sergey A. Dyshlovoy, Chau V. Minh, Valentin A. StonikSix new triterpenoids (1–6) and
the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one
were isolated from a Penares sp. sponge collected
from Vietnamese waters. Structures of the obtained compounds were
established by extensive 1D and 2D NMR spectroscopy and mass spectrometry.
Configurations of the triterpene epoxy lactones (1–4) were determined on the basis of NOESY and CD data and calculation
of spin coupling constants and confirmed by X-ray crystallographic
analysis of compound 2. The isolated triterpenoid 6 was cytotoxic against human leukemia HL-60 cells (IC50 = 9.7 μM).
