Is this bilayer expansion?

2012-06-05T13:32:20Z (GMT) by Ethan Perlstein Daniel Korostyshevsky
<p>A clathrin heavy chain (chc1) mutant that is resistant to the SSRI antidepressant sertraline/Zoloft exhibits what appears to be bilayer expansion under both steady state and sertraline-treated conditions. It is also possible that the expansion of electron lucent (that is, white) material is occurring inside the lumen of amphisomes (aka autophagolysosomes).</p> <p>What do you think? Please annotate in the comment thread below.</p> <p> </p>