Interaction of immune cells and oncolytic virus with tumor cells.

Susceptible (Uninfected) normal and tumor cells become infected by an oncolytic virus (vesicular stomatitis virus (VSV)). After successful viral propagation within the infected cells, infected cells undergo lysis (cell rupture) producing a progeny of new infectious viruses which spread and infect other susceptible cells. Debris from infected cells activates the virus-specific immune cells which then induces killing of infected cells and clearance of free virus. The tumor-specfic immune cells recognise (due to expression of tumor-associated antigens (TAAs)) and kill both uninfected and infected tumor cells.