Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites

<p>Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, <i>Heligmosomoides polygyrus bakeri</i> (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory–secretory (ES) products from Hp directly suppress osteoclast differentiation <i>in vitro</i>. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.</p>