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Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues

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posted on 2018-09-21, 20:45 authored by Guiyang Yao, Wei Wang, Lijiao Ao, Zhehong Cheng, Chunlei Wu, Zhengyin Pan, Ke Liu, Hongchang Li, Wu Su, Lijing Fang
To enable the large-scale synthesis of coibamide A, we developed an improved synthetic strategy for this class of cyclodepsipeptide. The versatility of the synthetic procedure was demonstrated by the preparation of a series of designed coibamide A analogues, which enabled the preliminary structure–activity relationship (SAR) studies for this compound. Although most modifications of coibamide A resulted in decrease or loss of the antiproliferativity, we found that versatile substitution at position 3 was well tolerated. Remarkably, a simplified analogue, [MeAla3-MeAla6]-coibamide (1f), not only showed nearly the same inhibition as coibamide A against the tested cancer cells but also significantly inhibited tumor growth in vivo. The improved synthetic strategy and the relevant trends of SAR disclosed in this study will be valuable for further optimization of the overall profile of coibamide A.

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