gtec_a_1113286_sm7014.doc (47 kB)
Immunotoxic effect of arsenic trioxide on Caenorhabditis elegans
journal contribution
posted on 2015-11-01, 00:00 authored by Yan Yu, Miao Zhao, Lili Yu, Xiaohong Pan, Lingling WuA Pseudomonas aeruginosa–Caenorhabditis elegans pathogenesis model was utilized to assess immunotoxic effects of arsenic trioxide (As2O3). After 2 h of As2O3 exposure, 500 µmol L−1 and 1 mmol L−1 As2O3 treatment significantly decreased median survivals of C. elegans (10 h after L4/adult molt). However, 2 h of As2O3 exposure caused no significant changes in the survivals rates of C. elegans (2 h after L4/adult molt). Notably, a significant dose-related immunoenhancement was observed in C. elegans (2 h after L4/adult molt) after 12 h of arsenite exposure.