Identification and development of adverse outcome pathways

The vision of EU-ToxRisk is to allow the paradigm shift of toxicity assessment, from in vivo testing towards reliable, animal-free hazard and risk assessment of chemicals. EUToxRisk developed various case studies on five main topics of toxicity: liver, lung, kidney, neuronal system and developmental and reproductive toxicity. The purpose of these case studies is to provide a proof of concept for the use of AOPs by integrating new developments in in vitro and in silico methods to describe the key biological events described in the AOPs. This poster displays the initial efforts towards fully developed AOPs.