Fig 3.tif (3.15 MB)
IPA interaction network for verteporfin and emetine, and differentially expressed genes from our atypical meningioma gene signature.
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posted on 2018-03-20, 17:39 authored by Zsolt Zador, Andrew T. King, Nophar GeifmanGenes and drugs candidates are represented as nodes, and are coloured based on fold-change of expression values, ranging from green (down-regulated in atypical meningioma) to red (up-regulated in atypical meningioma). Nodes in white represent genes that were not included in our atypical meningioma gene signature but serve as a link in the network to the candidate drugs. A line connects two nodes if there is any known relationship between the two; solid lines represent direct interactions while dotted lines represent indirect interactions.
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drug candidatesLINCSdrug repurposing Background Atypical meningiomasIntegrated Network-Based Cellular SignaturesIPAgene expression signaturegene expression profilesdrugs target signalGene Expression OmnibusConclusion Gene expressionNew drug candidatesYAPingenuity pathway analysisdrug-generated expression profilesERKdrug expression profilesgene expression signaturesBoard Institute Connectivity Map
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