Hypervalent Iodine Mediated <i>para</i>-Selective Fluorination of Anilides
2013-01-07T00:00:00Z (GMT) by
A metal-free method for the direct regioselective fluorination of anilides has been developed. In the presence of bis(<i>tert</i>-butylcarbonyloxy)iodobenzene (PhI(OPiv)<sub>2</sub>) and hydrogen fluoride-pyridine, the <i>para</i>-fluorination products of anilides were obtained in moderate to good yields. Because of its operational safety and the use of readily available reagents, this new procedure provides facile access to a variety of <i>para</i>-fluorinated anilides.